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International Journal of Immunology Research

Vol. 6, Issue 2, Part A (2024)

The role of TNF-α and response to TNF-α inhibitor in development of psoriatic arthritis among Iraqi psoriatic patients

Author(s):

Dr. Abdulrhman M Hassan Hadi

Abstract:

Background: Psoriatic arthritis (PsA) is a disease commonly appears after the onset of the characteristic cutaneous lesions of psoriasis. Synovial fluid and tissue in patients with Psoriatic arthritis demonstrates of high levels of pro-inflammatory cytokine such as tumor necrosis factor (TNF). 
Aim of the study: To demonstrate the frequency of psoriatic arthritis among psoriatic patients and potential role TNF-α in this disease. 
Subjects and Methods: One hundred psoriatic patients treated with Etanercept were enrolled in the present study, the diagnosis of each case was established by clinical examination done by a dermatologist. Inclusion criteria: One hundred psoriatic patients treated with biological drug (Etanercept). Blood sera were used to determine the level of TNF-α by using ELISA. 
Results: Psoriatic arthritis composed about 17% of psoriatic patients. Patients of old age and long duration with psoriasis are at risk to development of psoriatic arthritis. Regarding the response to treatment it was revealed that the non-responder patients more frequent of psoriatic arthritis (57.1%) than responder patients (6.3%). Furthermore, TNF-α level showed a highly significant difference between responder and non-responder patients (p<0.001).
Conclusion: These results may provide an additional evidence for frequency of psoriatic arthritis in Iraqi psoriatic patients.
 

Pages: 35-38  |  82 Views  30 Downloads


International Journal of Immunology Research
How to cite this article:
Dr. Abdulrhman M Hassan Hadi. The role of TNF-α and response to TNF-α inhibitor in development of psoriatic arthritis among Iraqi psoriatic patients. Int. J. Immunol. Res. 2024;6(2):35-38. DOI: 10.33545/26648865.2024.v6.i2a.47
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