Vol. 6, Issue 2, Part A (2024)

Exosomes, nanosized extracellular vesicles derived from various cell types, play a crucial role in intercellular communication, particularly within the immune system. Dendritic cells (DCs), as key antigen-presenting cells, release exosomes that carry specific phenotypic markers and functional molecules, influencing immune responses. This review aims to provide a comprehensive overview of the phenotypic characterization of exosomes derived from dendritic cells, discussing their biogenesis, molecular composition, and functional implications. We explore the role of DC-derived exosomes in immune modulation, their potential as biomarkers for disease diagnosis, and their therapeutic applications in immunotherapy. The review also addresses current challenges in the isolation and characterization of exosomes and highlights future directions for research in this rapidly evolving field.