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International Journal of Immunology Research

Vol. 6, Issue 2, Part A (2024)

A review study on enhancing immune response to cancer: Nanoparticle-mediated macrophage activation

Author(s):

Sudeshna Sengupta, Simika Modak, Camellia Banerjee, Shreyashi Basak, Alapan Pal and Malavika Bhattacharya

Abstract:

The combination of biotechnology and cancer immunotherapy represents a new chapter in the battle against cancer. This research explores a comprehensive approach to utilizing macrophages for cancer immunotherapy, focusing on nanoparticle-mediated activation. Macrophages, as essential immune system components, offer a promising avenue for cancer treatment due to their ability to consume and eliminate tumor cells. Using nanoparticles to deliver immunomodulatory drugs, we aim to enhance macrophage anti-tumor capabilities, thereby bolstering the immune response to cancer also the role of T and B cells, chemokines, and other immunological mediators is crucial in guiding the immune response to cancer. Tumor-associated macrophages (TAMs) play a dual role in tumor development and suppression, making them excellent targets for therapeutic intervention to complement existing Tumor immunotherapy strategies. The review explores the potential of cancer vaccines and nanoparticles in enhancing cancer immunotherapy. Cancer vaccines have shown potential in priming the immune system to identify and combat tumor cells, while nanoparticles offer unique advantages in delivering therapeutic compounds to the tumor microenvironment. By delineating these pathways, this initiative seeks to play a part in advancing new and effective immunotherapeutic approaches for treating cancer.

Pages: 01-10  |  372 Views  127 Downloads


International Journal of Immunology Research
How to cite this article:
Sudeshna Sengupta, Simika Modak, Camellia Banerjee, Shreyashi Basak, Alapan Pal and Malavika Bhattacharya. A review study on enhancing immune response to cancer: Nanoparticle-mediated macrophage activation. Int. J. Immunol. Res. 2024;6(2):01-10. DOI: 10.33545/26648865.2024.v6.i2a.25
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