Vol. 6, Issue 1, Part A (2024)

Superantigens are potent immunostimulatory molecules produced by certain bacteria and viruses, capable of triggering an overwhelming immune response that can lead to severe diseases such as toxic shock syndrome, autoimmune disorders, and certain types of sepsis. This review paper explores the current state of research on the efficacy of superantigen blockers in preventing toxin-induced immune dysregulation. We delve into the mechanisms of superantigen action, the development and function of various superantigen blockers, and the comparative analysis of previous studies that have evaluated their effectiveness. The review also discusses the challenges and future directions in the field, aiming to provide a comprehensive understanding of the potential of superantigen blockers in clinical settings.