Vol. 5, Issue 1, Part A (2023)

Thymus-derived T cells, also known as thymocytes, are essential components of the adaptive immune system. They develop and mature in the thymus, where they undergo a complex process of selection to ensure self-tolerance and the ability to recognize foreign antigens. This review explores the stages of thymocyte development, the critical mechanisms of positive and negative selection, and the functional diversity of mature T cells. Additionally, it discusses the impact of thymic involution with aging and the potential therapeutic strategies to rejuvenate thymic function. Understanding the development and function of thymus-derived T cells provides insight into maintaining immune homeostasis and developing novel immunotherapies.