Reza Ghaderi, Sobhan Gohari
Introduction: Alopecia areata is a chronic inflammatory disease and a common form of non-scarring recurrent hair loss, that involves hair follicles and sometimes nails. Today, studies suggest that some chemokines, expressed by epithelial cells, might have an important role in lymphocytes chemotaxis and skin inflammation. These chemokines especially might attract memory T cells toward themselves. Therefore, in this study we aim to investigate CCL 27 level in patient affected by alopecia areata and control group. Material and methods: In this case-control study, the study population consisted of patients with alopecia areata who referred to the private dermatology clinic in Birjand in 2019 as the case group and the control group was selected from patients referred to Birjand city Shafa laboratory. Inclusion criteria were: having informed consent, having no diabetes mellitus, thyroiditis, psoriasis, iron deficiency anemia, atopic dermatitis, and inflammatory skin diseases. Also, exclusion criteria were: topical or previous systemic treatment for the last 2 months, Patients with autoimmune diseases and systemic diseases. A blood sample of 5 ml was extracted from each case in case and control groups. The collected data were then entered into SPSS software ver. 16 and analyzed. Results:In this study 35 cases were present in each group. There was 27 (77.1%) male and 8 (22.9%) female present in both groups. Mean age in both groups 8/10 ± 57/31 all patients lived in urban areas. According to results of this study mean serum level of CCL 27 in both case and control groups was not significantly different (P>0.05). also there were no significant relation between serum level of CCL 27 with gender and age group in both case and control groups (P>0.05). Conclusions: There was no significant difference between serum level of CCL27 among case and control groups. Also, serum level of CCL27 showed no significant difference between gender and age groups (P>0.05).
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